u-Conotoxin GIIIB

Names

[ Name ]:
u-Conotoxin GIIIB

[Synonym ]:
Conotoxin GIIIB
U-conotoxin giiib
ARG-ASP-CYS-CYS-THR-HYP-HYP-ARG-LYS-CYS-LYS-ASP-ARG-GLN-CYS-LYS-HYP-GLN-ARG-CYS-CYS-ALA-NH2
mhu-conotoxin GIIIB
GEOGRAPHUTOXIN II
GTXII
M-CONOTOXIN GIIIB

Biological Activity

[Description]:

μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[Target]

NaV1.4 Channel[2]

[References]

[1]. orres NS. Activation of reverse Na+-Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603.

[2]. Garcia N, et al. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. Mol Neurobiol. 2022 Jul;59(7):4044-4064.

[3]. Hill JM, et al. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. 1996 Jul 9;35(27):8824-35.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₁H₁₇₅N₃₉O₃₀S₇

[ Molecular Weight ]:
2640.17

[ Exact Mass ]:
2638.14000

[ PSA ]:
1338.14000

Safety Information

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
UN 3462 6

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds

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