eIF4A3-IN-12

Names

[ CAS No. ]:
1402931-76-3

[ Name ]:
eIF4A3-IN-12

Biological Activity

[Description]:

eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

[References]

[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H25ClO7

[ Molecular Weight ]:
496.94

Related Compounds