KT-195

Names

[ Name ]:
KT-195

[Synonym ]:
Methanone, [4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-
[4-(4'-Methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone

Biological Activity

[Description]:

KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM; displays negligible activity against other serine hydrolases such as DAGLβ; induce a significant accumulation of 2-AG in Neuro2a cells; inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−; inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak.

[References]

References 1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007. 2. Yun B, et al. J Biol Chem. 2014 Jan 17;289(3):1491-504. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
658.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₆N₄O₂

[ Molecular Weight ]:
438.521

[ Flash Point ]:
352.2±34.3 °C

[ Exact Mass ]:
438.205566

[ LogP ]:
4.58

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310 + P330

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds

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