<Suppliers Price>

PI4KA inhibitor-F1

Names

[ CAS No. ]:
1402345-92-9

[ Name ]:
PI4KA inhibitor-F1

[Synonym ]:
3-Pyridinesulfonamide, 5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-
5-{2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]-3,4-dihydro-6-quinazolinyl}-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulfonamide
PI4KA inhibitor-F1

Biological Activity

[Description]:

GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> PI3K/Akt/mTOR >> PI4K

[Target]

PI4KA:8.0 (pIC50)

PI4KB:5.9 (pIC50)

PI3KA:5.8 (pIC50)

PI3KB:5.9 (pIC50)

PI3KG:5.9 (pIC50)

PI3KD:6.4 (pIC50)


[References]

[1]. Bojjireddy N, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):6120-32.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
744.3±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H18F5N5O4S

[ Molecular Weight ]:
603.52

[ Flash Point ]:
404.0±35.7 °C

[ Exact Mass ]:
603.099976

[ LogP ]:
4.43

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.646

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds