genz-682452

Names

[ Name ]:
genz-682452

[Synonym ]:
(3S)-1-Azabicyclo[2.2.2]oct-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-2-propanyl}carbamate
Carbamic acid, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
MFCD28502073
venglustat
Ibiglustat
genz-682452
Ansofaxine Hydrochloride

Biological Activity

[Description]:

Ibiglustat (Venglustat) is an inhibitor of glucosylceramide synthase extracted from patent WO 2015089067 A1, compound example 64.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

Ibiglustat is in phase II clinical trials for the treatment of Fabry's disease. Fabry disease, an X-linked disorder of glycosphingolipids that is caused by mutations of the GLA gene that codes for α-galactosidase A, leads to dysfunction of many cell types and includes a systemic vasculopathy[2]. Substrate reduction therapy is an approach that reduces the synthesis of lipids reaching the lysosome through inhibition of glucosylceramide synthase (GCS)[1].

[References]

[1]. WO 2015089067 A1

[2]. Schiffmann R, et al. Fabry disease. Handb Clin Neurol. 2015;132:231-48.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₀H₂₄FN₃O₂S

[ Molecular Weight ]:
389.487

[ Exact Mass ]:
389.157318

[ LogP ]:
4.13

[ Index of Refraction ]:
1.613

[ Storage condition ]:
2-8℃

genz-682452

Names

Biological Activity

Chemical & Physical Properties

Related Compounds