CORT 118335
Names
[ CAS No. ]:
1400902-13-7
[ Name ]:
CORT 118335
[Synonym ]:
6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-(4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]-
Biological Activity
[Description]:
CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.
[In Vitro]
CORT 118335 (Miricorilant, C118335)?is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo.
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Molecular Formula ]:
C24H23F3N2O2
[ Molecular Weight ]:
428.447
[ Exact Mass ]:
428.171173
[ LogP ]:
6.21
[ Index of Refraction ]:
1.562