RGFP966

Names

[ Name ]:
RGFP966

[Synonym ]:
2-Propenamide (N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]
RGFP966

Biological Activity

[Description]:

(E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC3[1]

[References]

[1]. Jia H, et al. The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice. PLoS One. 2016 Mar 31;11(3):e0152498.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉FN₄O

[ Molecular Weight ]:
362.40000

[ Exact Mass ]:
362.15400

[ PSA ]:
72.94000

[ LogP ]:
4.62390

[ Storage condition ]:
-20°C

Related Compounds

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