depudecin

Names

[ Name ]:
depudecin

[Synonym ]:
4,5:8,9-Dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeca-1,6-dienitol
(−)-Depudecin
(2R,3S,4S,5E,7S,8S,9R)-2,9-dihydroxy-3,4,7,8-diepoxy-undeca-5,10-diene
4,5:8,9-dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeco-1,6-dienitol
* (1R)-[(2S,3S)-3-[(E)-2-[(2S,3S)-3-[(1R)-Hydroxyethyl]oxiran-2-yl]vinyl]oxiran-2-yl]-2-propen-1-ol
(1R)-1-[(2S,3S)-3-[2-[(2S,3S)-3-[(1R)-1-hydroxyethyl]oxiran-2-yl]ethenyl]oxiran-2-yl]prop-2-en-1-ol

Biological Activity

[Description]:

Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> HDAC

[In Vitro]

Depudecin (48 h) 可以诱导由 ras 和 src 癌基因双重转化的 NIH3T3 细胞的扁平表型[1]。

[References]

[1]. Hannah T Reynolds, et al. Differential Retention of Gene Functions in a Secondary Metabolite Cluster. Mol Biol Evol. 2017 Aug 1;34(8):2002-2015.

[2]. M Matsumoto, et al. Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola. J Antibiot (Tokyo). 1992 Jun;45(6):879-85.

Chemical & Physical Properties

[ Density]:
1.415g/cm3

[ Boiling Point ]:
369.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₆O₄

[ Molecular Weight ]:
212.24200

[ Flash Point ]:
177.2ºC

[ Exact Mass ]:
212.10500

[ PSA ]:
65.52000

[ LogP ]:
0.00510

[ Vapour Pressure ]:
5.83E-07mmHg at 25°C

[ Index of Refraction ]:
1.706

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.