SI-113

SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells; blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells; potentiates the effects of paclitaxel on cell viability; active in vivo.

References 1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18. 2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25. 3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84. 4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26. View Related Products by Target SGK