DHODH-IN-13
Names
[ CAS No. ]:
1364791-86-5
[ Name ]:
DHODH-IN-13
Biological Activity
[Description]:
DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1].
[Related Catalog]:
[Target]
IC50: 4.3 μM for (Rat liver DHODH)[1]
[In Vitro]
DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C10H6F3N3O3
[ Molecular Weight ]:
273.17