PKC substrate (MBP)

Names

[ Name ]:
PKC substrate (MBP)

[Synonym ]:
pGlu-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu
MBP 4-14

Biological Activity

[Description]:

[pGlu4]-Myelin Basic Protein (4-14) is the phosphorylated 4-14 fragment (EKRPSQRSKYL) of myelin basic protein (MBP)[1]. [pGlu4]-Myelin Basic Protein (4-14) surrounds the serine residue in position 8 of the myelin basic protein[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Durocher Y, et al. Activation of an 85 kDa ribosomal S6 kinase during serotonin-induced oocyte maturation. Int J Dev Biol. 1996 Jun;40(3):557-66.

[2]. Loog M, et al. Comparison of Substrate Specificities of Protein Kinases A and C Based on Peptide Substrates[J]. Bioorganic Chemistry, 1994, 22(3): 328-336.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₀H₁₀₀N₂₀O₁₇

[ Molecular Weight ]:
1373.56000

[ Exact Mass ]:
1372.76000

[ PSA ]:
628.23000

[ LogP ]:
1.00040

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

A synthetic peptide substrate for selective assay of protein kinase C.

Biochem. Biophys. Res. Commun. 166 , 1220, (1990)

Among various phosphate acceptor proteins and peptides so far tested, a synthetic peptide having the sequence surrounding Ser(8) of myelin basic protein, Gln-Lys-Arg-Pro-Ser(8)-Gln-Arg-Ser-Lys-Tyr-Leu...