UNC-1062

Names

[ Name ]:
UNC-1062

[Synonym ]:
UNC-1062
T7755XP5Y6
Cyclohexanol, 4-[6-(butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, trans-
trans-4-{6-(Butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}cyclohexanol

Biological Activity

[Description]:

UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM; shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3); inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells.

[References]

References 1. Schlegel J, et al. J Clin Invest. 2013 May;123(5):2257-67. 2. Liu J, et al. Eur J Med Chem. 2013 Jul;65:83-93. 3. von Mässenhausen A, et al. Oncotarget. 2016 May 31;7(22):32678-94. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
744.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₄N₆O₄S

[ Molecular Weight ]:
514.640

[ Flash Point ]:
403.8±35.7 °C

[ Exact Mass ]:
514.236206

[ LogP ]:
2.66

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.697

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.