HS-PEG3-CH2CH2N3

Names

[ CAS No. ]:
1347750-79-1

[ Name ]:
HS-PEG3-CH2CH2N3

Biological Activity

[Description]:

HS-PEG3-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₇N₃O₃S

[ Molecular Weight ]:
235.30400

[ Exact Mass ]:
235.09900

[ PSA ]:
116.24000

[ LogP ]:
0.72906

Precursor & DownStream

Precursor

DownStream

Related Compounds

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