Sibiriline

Names

[ Name ]:
Sibiriline

[Synonym ]:
Phenol, 4-(1H-pyrrolo[2,3-b]pyridin-2-yl)-
4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol

Biological Activity

[Description]:

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.

[References]

References 1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176. View Related Products by Target RIP kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
457.4±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₀N₂O

[ Molecular Weight ]:
210.231

[ Flash Point ]:
230.4±24.6 °C

[ Exact Mass ]:
210.079315

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.726

Related Compounds

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