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Rivastigmine carbamate impurity

Names

[ CAS No. ]:
1346242-31-6

[ Name ]:
Rivastigmine carbamate impurity

[Synonym ]:
3-Nitrophenyl ethyl(methyl)carbamate
Rivastigmine tartrate impurity,carbamate impurity-[USP]
Carbamic acid,N-ethyl-N-methyl-,3-nitrophenyl ester
UNII-5EM63X2EYP

Biological Activity

[Description]:

Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Ziwei Chen, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. Eur J Med Chem. 2017 Jan 5;125:784-792.

[2]. Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45(17):3684-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H12N2O4

[ Molecular Weight ]:
224.21300

[ Exact Mass ]:
224.08000

[ PSA ]:
75.36000

[ LogP ]:
2.56850

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds