Dynamin IN-2

Names

[ Name ]:
Dynamin IN-2

Biological Activity

[Description]:

Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Cytoskeleton >> Dynamin

[Target]

IC50: 1.0 ± 0.2 μM (dyn I GTPase), 9.5 ± 2.5 μM (CME)[1]

[References]

[1]. Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁ClN₂O

[ Molecular Weight ]:
364.87

Related Compounds

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