EIPA hydrochloride

Names

[ Name ]:
EIPA hydrochloride

Biological Activity

[Description]:

EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM[1]. EIPA also inhibits Na+/H+-exchanger (NHE)[2] and macropinocytosis[3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

IC50: 10.5 μM (TRPP3 channel)[1] NHE[2] Macropinocytosis[3]

[References]

[1]. Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.

[2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.

[3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₉Cl₂N₇O

[ Molecular Weight ]:
336.22

[ Storage condition ]:
2-8℃

Related Compounds

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