beta-hydroxyethoxyacetic acid

Names

[ Name ]:
beta-hydroxyethoxyacetic acid

[Synonym ]:
(2-hydroxy-ethoxy)-acetic acid
Acetic acid,2-(2-hydroxyethoxy)
(2-Hydroxy-aethoxy)-essigsaeure
Glykoloxyessigsaeure

Biological Activity

[Description]:

(2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the main urinary metabolite of 1,4-Dioxane. (2-Hydroxyethoxy)acetic acid is a reliable and sensitive shortterm biomarker in urine[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

(2-Hydroxyethoxy)acetic acid (HEAA) exists in a pH-dependent equilibrium with the cyclic lactone dioxan-2-one, whereby the open-chain form of (2-Hydroxyethoxy)acetic acid is found to be stable under acidic conditions[1].

[In Vivo]

The main metabolic pathway of 1,4-Dioxane is oxidized by cytochrome P450 monooxygenase to (2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid; HEAA), which is then rapidly excreted in urine[1].

[References]

[1]. Elisabeth Eckert, et al. Reliable quantitation of β-hydroxyethoxyacetic acid in human urine by an isotope-dilution GC-MS procedure. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 15;935:80-4.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
323.8ºC at 760mmHg

[ Melting Point ]:
44ºC

[ Molecular Formula ]:
C₄H₈O₄

[ Molecular Weight ]:
120.10400

[ Flash Point ]:
147.3ºC

[ Exact Mass ]:
120.04200

[ PSA ]:
66.76000

[ Vapour Pressure ]:
2.01E-05mmHg at 25°C

[ Index of Refraction ]:
1.458

Safety Information

[ HS Code ]:
2918990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%