1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol

Names

[ Name ]:
1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol

[Synonym ]:
1-(4-hydroxybenzyl)-4-methoxyphenthrene-2,7-diol
2,7-Phenanthrenediol,1-[(4-hydroxyphenyl)methyl]-4-methoxy
1-(4'-hydroxybenzyl)-4-methoxyphenanthrene-2,7-diol
1-(p-hydroxybenzyl)-4-methoxyphenanthrene-2,7-diol

Biological Activity

[Description]:

BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

BChE:2.1 ± 0.3 μM (IC50)

AChE

[In Vitro]

BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively[1].BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82[1].

[References]

[1]. Liu Y, et al. Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors. Sci Rep. 2022 Aug 11;12(1):13649.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₈O₄

[ Molecular Weight ]:
346.37600

[ Exact Mass ]:
346.12100

[ PSA ]:
69.92000

[ LogP ]:
4.70920

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.