Prostaglandin B2

Names

[ Name ]:
Prostaglandin B2

[Synonym ]:
(5Z,13E,15R)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid
MFCD00065730
EINECS 234-237-8
Prostaglandin B2
(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid PGB2
Prosta-5,8(12),13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15R)-

Biological Activity

[Description]:

Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Endocrinology

[Target]

Human Endogenous Metabolite

[References]

[1]. Greenberg S, Engelbrecht JA, Wilson WR. Prostaglandin B2-induced cutaneous vasoconstriction of the canine hind paw. Circ Res. 1974 Apr;34(4):491-7.

[2]. van den Berk LC, et al. Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2. Stem Cells Dev. 2014 Jul 15;23(14):1582-93.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
537.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₀O₄

[ Molecular Weight ]:
334.45

[ Flash Point ]:
292.6±26.6 °C

[ Exact Mass ]:
334.214417

[ PSA ]:
74.60000

[ LogP ]:
3.24

[ Appearance of Characters ]:
solution

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
−20°C

[ Water Solubility ]:
ethanol: ~100 mg/mL

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319-H336

[ Supplemental HS ]:
Repeated exposure may cause skin dryness or cracking.

[ Precautionary Statements ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn,Xi,F

[ Risk Phrases ]:
20/21/22-67-66-36-11

[ Safety Phrases ]:
36/37-26

[ RIDADR ]:
UN 1231 3/PG 2

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Identification of prostamides, fatty acyl ethanolamines, and their biosynthetic precursors in rabbit cornea.

J. Lipid Res. 56 , 1419-33, (2015)

Arachidonoyl ethanolamine (anandamide) and pros-taglandin ethanolamines (prostamides) are biologically active derivatives of arachidonic acid. Although available through different precursor phospholip...

Differences in the Neuroprotective Effect of Orally Administered Virgin Olive Oil (Olea europaea) Polyphenols Tyrosol and Hydroxytyrosol in Rats.

J. Agric. Food Chem. 63 , 5957-63, (2015)

The neuroprotective effect of virgin olive oil (VOO) polyphenols has been related to their antioxidant effect. The main objective was to analyze how tyrosol and hydroxytyrosol contribute to the antiox...

Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2.

Stem Cells Dev. 23(14) , 1582-93, (2014)

Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long cul...