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Dolutegravir intermediate-1

Names

[ CAS No. ]:
1335210-23-5

[ Name ]:
Dolutegravir intermediate-1

[Synonym ]:
1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid
2,5-Pyridinedicarboxylic acid, 1-(2,2-dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-, 2-methyl ester
1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
Dolutegravir intermediate-1
1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester

Biological Activity

[Description]:

Dolutegravir intermediate-1 is a novel synthetic intermediate of dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-l infection.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others

[References]

[1]. Sivaram Prasad, et al. Process for the preparation of dolutegravir . WO 2016125192 A2.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
474.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H17NO8

[ Molecular Weight ]:
315.276

[ Flash Point ]:
240.5±28.7 °C

[ Exact Mass ]:
315.095428

[ PSA ]:
113.29000

[ LogP ]:
-1.00

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.536

[ Storage condition ]:
2-8℃

Related Compounds