Debio 0617B

Names

[ Name ]:
Debio 0617B

[Synonym ]:
N-{4-Chloro-3-[2-{[4-(methylcarbamoyl)phenyl]amino}-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]phenyl}-4-(trifluoromethyl)-2-pyridinecarboxamide
MFCD30749186
2-Pyridinecarboxamide, N-[4-chloro-3-[7,8-dihydro-2-[[4-[(methylamino)carbonyl]phenyl]amino]pyrido[4,3-d]pyrimidin-6(5H)-yl]phenyl]-4-(trifluoromethyl)-

Biological Activity

[Description]:

Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[References]

[1]. Maximilien Murone, et al. The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34⁺ Stem/Progenitor Cells. Mol Cancer Ther. 2017 Aug;16(8):1497-1510.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₂₃ClF₃N₇O₂

[ Molecular Weight ]:
581.976

[ Exact Mass ]:
581.155396

[ LogP ]:
4.03

[ Index of Refraction ]:
1.659

Related Compounds

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