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L-Norleucine-d9

Names

[ CAS No. ]:
1331889-36-1

[ Name ]:
L-Norleucine-d9

[Synonym ]:
L-(3,3,4,4,5,5,6,6,6-2H9)Norleucine
(S)-2-Aminohexanoic Acid-d9
L-Norleucine-3,3,4,4,5,5,6,6,6-d9

Biological Activity

[Description]:

L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Cancer
Research Areas >> Infection

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37.

[3]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
234.0±23.0 °C at 760 mmHg

[ Melting Point ]:
>280° C (dec.)

[ Molecular Formula ]:
C6H4D9NO2

[ Molecular Weight ]:
140.23

[ Flash Point ]:
95.3±22.6 °C

[ Exact Mass ]:
140.151123

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.465

Related Compounds