Olopatadine-d3 (hydrochloride)
Names
[ CAS No. ]:
1331635-21-2
[ Name ]:
Olopatadine-d3 (hydrochloride)
[Synonym ]:
Olopatadine-d3 (hydrochloride)
Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-[3-(methylmethyl-d3-amino)propylidene]-, (11E)-, hydrochloride (1:1)
[(11E)-11-(3-{Methyl[(2H3)methyl]amino}propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetic acid hydrochloride (1:1)
Biological Activity
[Description]:
Olopatadine-d3 hydrochloride (ALO4943A-d3) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis[1][2].
[Related Catalog]:
[In Vitro]
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[References]
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.
[3]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97.
[4]. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.
Chemical & Physical Properties
[ Molecular Formula ]:
C21H21D3ClNO3
[ Molecular Weight ]:
376.892
[ Exact Mass ]:
376.163300