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Epi-Cryptoacetalide

Names

[ CAS No. ]:
132152-57-9

[ Name ]:
Epi-Cryptoacetalide

[Synonym ]:
Spiro[furan-2(3H),3'(1'H)-naphtho[1,2-c]furan]-1'-one, 4,5,6',7',8',9'-hexahydro-4,6',6'-trimethyl-, (2R,4R)-
(2R,4R)-4,6',6'-Trimethyl-4,5,6',7',8',9'-hexahydro-1'H,3H-spiro[furan-2,3'-naphtho[1,2-c]furan]-1'-one

Biological Activity

[Description]:

Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[Target]

Ki: 0.3 μM (ER-α) and 1.92 μM (EP2 subtype)[1]


[In Vitro]

Epi-cryptoacetalide 是丹参中的一种成分，具有散瘀止痛、活血通经、除烦等功效； 月经不调，经闭，痛经，脘腹作痛，胸腹刺痛，热痹，疮疡疮毒，失眠，肝脾肿痛，心绞痛。

[References]

[1]. Herbert Situmorang, et al. IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor. Ann Med Surg (Lond). 2021 Jun 17;67:102459.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
464.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H22O3

[ Molecular Weight ]:
286.366

[ Flash Point ]:
199.8±23.3 °C

[ Exact Mass ]:
286.156891

[ LogP ]:
4.39

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds