Dihydrocucurbitacin B

Names

[ Name ]:
Dihydrocucurbitacin B

[Synonym ]:
Estr-5-ene-3,11-dione, 17-[(1R)-5-(acetyloxy)-1-hydroxy-1,5-dimethyl-2-oxohexyl]-2,16-dihydroxy-4,4,9,14-tetramethyl-, (2β,9β,10α,16α,17β)-
(2S,4R,9β,16α)-2,16,20-Trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholest-5-en-25-yl acetate
23,24-dihydrocucurbitacin B
Dihydrocucurbitacin B

Biological Activity

[Description]:

Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Escandell JM, et al. Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation. J Pharmacol Exp Ther. 2007 Sep;322(3):1261-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
692.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₈O₈

[ Molecular Weight ]:
560.719

[ Flash Point ]:
215.4±25.0 °C

[ Exact Mass ]:
560.334900

[ PSA ]:
138.20000

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±4.9 mmHg at 25°C

[ Index of Refraction ]:
1.559

[ Storage condition ]:
2-8℃

Related Compounds

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