Cresol
Names
[ CAS No. ]:
1319-77-3
[ Name ]:
Cresol
[Synonym ]:
hydroxytoluene
Cresol, o-
tekresol
Cresol, ortho-
2-hydroxytoluene
Phenol, 2-methyl-
bacillol
m-cresol,p-cresol,mixture of
o-Methylphenol
ortho-cresol
o-Cresol
kresolen
o-Hydroxytoluene
Cresol, o-isomer
p-cresol,m-cresol,mixture of
2-hydroxy-1-methylbenzene
o-Cresol [UN2076] [Poison, Corrosive]
2-cresol
TRICRESOL
krezol
cresylic acid
Cresylol
cresoli
Monomethyl phenol
EINECS 215-293-2
kresole
MFCD00151099
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
191.0±0.0 °C at 760 mmHg
[ Melting Point ]:
-1--2°C
[ Molecular Formula ]:
C7H8O
[ Molecular Weight ]:
108.138
[ Flash Point ]:
81.1±0.0 °C
[ Exact Mass ]:
108.057518
[ PSA ]:
60.69000
[ LogP ]:
1.94
[ Vapour Pressure ]:
0.4±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.546
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
1.932 g/100 mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GO5950000
- CHEMICAL NAME :
- Cresol
- CAS REGISTRY NUMBER :
- 1319-77-3
- BEILSTEIN REFERENCE NO. :
- 0506719
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 44
- MOLECULAR FORMULA :
- C7-H8-O
- MOLECULAR WEIGHT :
- 108.15
- WISWESSER LINE NOTATION :
- QR X1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 177 mg/kg
- TOXIC EFFECTS :
- Blood - other hemolysis with or without anemia Blood - other changes
- REFERENCE :
- CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 130,1319,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 114 mg/kg
- TOXIC EFFECTS :
- Vascular - other changes
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,404,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1454 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB214-270
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 760 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KSGZA3 Kyushu Shika Gakkai Zasshi. Journal of the Kyushu Dental Society. (c/o Kyushu Shika Daigaku, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Japan) V.1- 1933- Suspended 1941-50. Volume(issue)/page/year: 36,932,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 gm/kg
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977 *** REVIEWS *** ACGIH TLV-TWA 22 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD:skin 5 ppm (22 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,61,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (23 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993 OEL-INDIA:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm;STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CRESOL, all isomers-air:10H TWA 2.3 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 20380 No. of Facilities: 8215 (estimated) No. of Industries: 86 No. of Occupations: 78 No. of Employees: 71952 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 20380 No. of Facilities: 7461 (estimated) No. of Industries: 84 No. of Occupations: 65 No. of Employees: 132742 (estimated) No. of Female Employees: 28184 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311-H314-H341-H412
[ Precautionary Statements ]:
P201-P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R20;R24/25;R34;R52/53;R68
[ Safety Phrases ]:
S26-S36/37/39-S45-S61
[ RIDADR ]:
UN 2076 6.1/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
GO5950000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
2707991000
Customs
[ HS Code ]: 2707991000
Articles
J. Bacteriol. 190(19) , 6493-500, (2008)
p-Cresol methylhydroxylases (PCMH) from aerobic and facultatively anaerobic bacteria are soluble, periplasmic flavocytochromes that catalyze the first step in biological p-cresol degradation, the hydr...
On the decoupling of relaxation modes in a molecular liquid caused by isothermal introduction of 2 nm structural inhomogeneities.J. Phys. Chem. B 115(48) , 13994-9, (2011)
To support a new interpretation of the origin of the dynamic heterogeneity observed pervasively in fragile liquids as they approach their glass transition temperatures T(g), we demonstrate that the in...
Cresols utilization by Trametes versicolor and substrate interactions in the mixture with phenol.Biodegradation 21(4) , 625-35, (2010)
The ability of the white rot fungus Trametes versicolor strain 1 to degrade and utilize methylated phenols (cresols) was established for the first time in a medium not containing any other carbon comp...