YF-2

Names

[ Name ]:
YF-2

[Synonym ]:
N-[4-chloro-2-(propan-2-yloxy)phenyl]-2,2-dimethylpropanamide
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide
Propanamide,N-[4-chloro-2-(1-methylethoxy)phenyl]-2,2-dimethyl

Biological Activity

[Description]:

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

Research Areas >> Neurological Disease

[Target]

CBP:2.75 μM (EC50)

PCAF:29.04 μM (EC50)

GCN5:49.31 μM (EC50)

[In Vitro]

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

[In Vivo]

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

[References]

[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂ClF₃N₂O₃

[ Molecular Weight ]:
430.84800

[ Exact Mass ]:
430.12700

[ PSA ]:
54.29000

[ LogP ]:
5.33420

[ Storage condition ]:
2-8℃

Related Compounds

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