5-Aminosalicylic acid-d3

Names

[ CAS No. ]:
1309283-32-6

[ Name ]:
5-Aminosalicylic acid-d3

[Synonym ]:
Benzoic-2,4,5-d3 acid, 3-amino-6-hydroxy-
5-Amino-2-hydroxy(2H3)benzoic acid

Biological Activity

[Description]:

5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cytoskeleton >> PAK
Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> PAK

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.;Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells i

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
403.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H4D3NO3

[ Molecular Weight ]:
156.154

[ Flash Point ]:
198.1±27.3 °C

[ Exact Mass ]:
156.061417

[ LogP ]:
0.46

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.691

Related Compounds