4,9-Anhydrotetrodotoxin

Names

[ Name ]:
4,9-Anhydrotetrodotoxin

[Synonym ]:
Anhydro-epitetrodotoxin
anhydrotetrodotoxin

Biological Activity

[Description]:

4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[In Vitro]

4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].

[References]

[1]. Nicholas Denomme, et al. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neurosci Lett. 2020 Apr 17;724:134853.

Chemical & Physical Properties

[ Density]:
3.07g/cm3

[ Boiling Point ]:
725.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₄N₂O₂

[ Molecular Weight ]:
206.24100

[ Flash Point ]:
392.6ºC

[ Exact Mass ]:
206.10600

[ PSA ]:
56.06000

[ LogP ]:
0.87730

[ Vapour Pressure ]:
2.63E-24mmHg at 25°C

[ Index of Refraction ]:
2.298

Precursor & DownStream

Precursor

DownStream

Related Compounds

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