H-D-Phe-Ome HCl

Names

[ Name ]:
H-D-Phe-Ome HCl

[Synonym ]:
Methyl D-phenylalaninate hydrochloride (1:1)
MFCD00066112
H-D-Phe-OMe·HCl
L-Phenylalanine, methyl ester, hydrochloride (1:1)
D-Phenylalanine Methyl Ester Hydrochloride
EINECS 219-934-7
D-Phenylalanine, methyl ester, hydrochloride (1:1)
Methyl L-phenylalaninate hydrochloride (1:1)
methyl (2R)-2-amino-3-phenylpropanoate,hydrochloride
L-Phenylalanine methyl ester hydrochloride
H-D-Phe-OMe.HCl
H-D-Phe-Ome HCl

Biological Activity

[Description]:

D-Phe-OMe monohydrochloride is a phenylalanine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-891.

Chemical & Physical Properties

[ Density]:
1.1g/cm3

[ Boiling Point ]:
264.2ºC at 760 mmHg

[ Melting Point ]:
159-163 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₄ClNO₂

[ Molecular Weight ]:
215.677

[ Flash Point ]:
126ºC

[ Exact Mass ]:
215.071304

[ PSA ]:
52.32000

[ LogP ]:
2.23170

[ Vapour Pressure ]:
0.00986mmHg at 25°C

[ Index of Refraction ]:
-37.0 ° (C=2, EtOH)

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.

J. Med. Chem. 53 , 2354-63, (2010)

Here we studied the capacity of N-MePhe-(N-MePhe)(3)-CONH(2), Cha-(N-MePhe)(3)-CONH(2), and 2Nal-(N-MePhe)(3)-CONH(2) to carry various drugs (cargos) in in vitro blood-brain barrier (BBB) models in or...

Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.

Blood 79(4) , 964-71, (1992)

L-leucine methyl ester (Leu-OMe), Leu-Leu-OMe, Phe-OMe, and Glu-(OMe)2 are toxic to mononuclear phagocytes (M phi) and neutrophils. In the present studies, the mechanism of this toxicity was examined....

Enzyme activity evaluation of organic solvent-treated phenylalanine ammonia lyase.

Biotechnol. Prog. 27(6) , 1554-60, (2011)

The direct one-step synthesis of L-phenylalanine methyl ester in an organic-aqueous biphasic system using phenylalanine ammonia lyase (E.C.4.3.1.5, PAL) containing Rhodotorula glutinis yeast whole cel...