3'-Azido-3'-deoxy-5-methylcytidine

Names

[ CAS No. ]:
1282040-14-5

[ Name ]:
3'-Azido-3'-deoxy-5-methylcytidine

Biological Activity

[Description]:

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

HIV-1:0.06 μM (EC50, in PBM cells)

XMRV:43.5 μM (CC50, in MCF-7 cells)


[References]

[1]. Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H14N6O4

[ Molecular Weight ]:
282.26

[ Storage condition ]:
2-8°C

Related Compounds