NHI 2

Names

[ Name ]:
NHI 2

[Synonym ]:
Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
1H-Indole-2-carboxylic acid, 1-hydroxy-6-phenyl-4-(trifluoromethyl)-, methyl ester

Biological Activity

[Description]:

NHI-2 is a potent inhibitor of LDH-A. NHI-2 is an efficient anti-glycolytic agent. NHI-2 has the potential for the research of cancer disease[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[References]

[1]. Granchi C, et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org Biomol Chem. 2013;11(38):6588-6596.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
495.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂F₃NO₃

[ Molecular Weight ]:
335.277

[ Flash Point ]:
253.6±31.5 °C

[ Exact Mass ]:
335.076935

[ LogP ]:
5.14

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.567

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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