Sarafotoxin A

Names

[ Name ]:
Sarafotoxin A

[Synonym ]:
SRTX-A,S6A
M.W. 2514.85 C105H156N28O34S5
H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH
CHPG Sodium salt
CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP
SARAFOTOXIN A
SARAFOTOXIN S6A1

Biological Activity

[Description]:

Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

Research Areas >> Neurological Disease

[Target]

ETB

ETA

[In Vitro]

Sarafotoxin S6a is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta[1].

[References]

[1]. P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₅H₁₅₆N₂₈O₃₄S₅

[ Molecular Weight ]:
2514.85000

[ Exact Mass ]:
2512.99000

[ PSA ]:
1144.17000

[ LogP ]:
1.82910

Related Compounds

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