p38α inhibitor 4

Names

[ Name ]:
p38α inhibitor 4

Biological Activity

[Description]:

p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[Target]

p38α:1.2 μM (IC50)

[References]

[1]. ACS Chem. Biol., Article ASAPDOI: 10.1021/cb1002619Publication Date (Web): November 23, 2010

[2]. Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₇F₆N₃O

[ Molecular Weight ]:
347.22

[ Exact Mass ]:
347.04900

[ PSA ]:
61.80000

[ LogP ]:
4.36810

Related Compounds

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