JTZ-951 hydrochloride

Names

[ Name ]:
JTZ-951 hydrochloride

Biological Activity

[Description]:

A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2; increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats. Anemia Phase 2 Clinical

[References]

References 1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325. View Related Products by Target HIF/HIF Prolyl-hydroxylase Anemia

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇ClN₄O₄

[ Molecular Weight ]:
376.797

Related Compounds

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