QWF

Names

[ Name ]:
QWF

[Synonym ]:
(R)-2-Amino-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid
BOC-D-tryptophan
Boc-Gln-D-Trp(CHO)-Phe-OBzl

Biological Activity

[Description]:

QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

IC50: 0.09 μM (substance P)[1]

[References]

[1]. Hagiwara D, et al. Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J Med Chem. 1992 May 29;35(11):2015-25.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Molecular Formula ]:
C₃₈H₄₃N₅O₈

[ Molecular Weight ]:
697.78

[ Exact Mass ]:
697.31100

[ PSA ]:
199.38000

[ LogP ]:
6.97340

[ Index of Refraction ]:
1.609

Related Compounds

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