Acetyl-Hirudin (54-65) (sulfated)

Names

[ Name ]:
Acetyl-Hirudin (54-65) (sulfated)

[Synonym ]:
Glutamine, N-acetylglycyl-α-aspartylphenylalanyl-α-glutamyl-α-glutamylisoleucylprolyl-α-glutamyl-α-glutamyl-O-sulfotyrosylleucyl-
N-ACETYL-HIRUDIN AC-[TYR(SO3H)63]-FRAGMENT 54-65
acetyl-[tyr(so3h)63]-hirudin fragment 54-65
N-Acetylglycyl-α-aspartylphenylalanyl-α-glutamyl-α-glutamylisoleucylprolyl-α-glutamyl-α-glutamyl-O-sulfotyrosylleucylglutamine
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN-OH
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN
N-acetyl-(tyr(so3H)63)-hirudin *fragment 54-65
ACETYL-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR[SO3H]-LEU-GLN
AC-HIRUDIN (54-65) (SULFATED)

Biological Activity

[Description]:

Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₆₈H₉₅N₁₃O₂₉S

[ Molecular Weight ]:
1590.617

[ Exact Mass ]:
1589.607910

[ PSA ]:
679.28000

[ LogP ]:
-0.55

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Related Compounds

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