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KS 176

Names

[ CAS No. ]:
1253452-78-6

[ Name ]:
KS 176

[Synonym ]:
KS176

Biological Activity

[Description]:

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).Target: BCRPThe more detailed information please refer to Compound 9 in the reference.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP
Research Areas >> Cancer

[References]

[1]. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505.


[Related Small Molecules]

Ko 143 | elacridar | Fumitremorgin C | YHO-13177 | YHO-13351 | (S)-ML753286 | Zamicastat

Chemical & Physical Properties

[ Molecular Formula ]:
C22H19N3O5

[ Molecular Weight ]:
405.40300

[ Exact Mass ]:
405.13200

[ PSA ]:
124.25000

[ LogP ]:
4.30340

[ Storage condition ]:
2-8℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds