Microtubule inhibitor 3

Names

[ CAS No. ]:
1236141-96-0

[ Name ]:
Microtubule inhibitor 3

Biological Activity

[Description]:

Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Ding Z,et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H23FN4O3

[ Molecular Weight ]:
458.48

Related Compounds