TAK-448
Names
Biological Activity
[Description]:
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].
[Related Catalog]:
[Target]
IC50: 460 pM (KISS1R)[1] EC50: 632 pM (KISS1R)[1]
[In Vivo]
TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2]. Animal Model: Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats) Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.3 mg/kg, 3 mg/kg Administration: Given i.h.; dosings on day 0 and 28 Result: Had greater anti-tumor effects in VCaP xenograft model.
[References]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C58H80N16O14
[ Molecular Weight ]:
1225.36
[ Exact Mass ]:
1224.604004
[ LogP ]:
0.29
[ Index of Refraction ]:
1.679
[ Storage condition ]:
2-8℃