(Z)-GW 5074

Names

[ CAS No. ]:
1233748-60-1

[ Name ]:
(Z)-GW 5074

Biological Activity

[Description]:

(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

c-Raf


[References]

[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H8Br2INO2

[ Molecular Weight ]:
520.94

Related Compounds