Laninamivir octanoate hydrate

Names

[ Name ]:
Laninamivir octanoate hydrate

[Synonym ]:
UNII-MCG28BI87W
Laninamivir octanoate hydrate (JAN)
Laninamivir octanoate monohydrate

Biological Activity

[Description]:

Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[In Vitro]

Laninamivir octanoate (CS-8958) 对 H1N1 病毒株、H3N2 病毒株和 H2N2 (A/Singapore/1/57) 病毒株具有抑菌活性，IC50 分别为 631-1170 nM、39.2-221 nM 和 128 nM [1]。

[In Vivo]

Laninamivir octanoate (CS-8958；95μg/kg；鼻内的管理；3 次) 在感染前 4 h、感染后 4 h 和 17 h 处理，在小鼠感染模型中均有明显的延长寿命效果[1]。 Animal Model: Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34[1] Dosage: 0.2 μmol/kg (95 μg/kg) Administration: Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection Result: Showed life-prolonging effect in infected model.

[References]

[1]. Makoto Yamashita, et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92.

[2]. Hideyuki Ikematsu, et al. Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza. Expert Rev Anti Infect Ther. 2011 Oct;9(10):851-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₈N₄O₉

[ Molecular Weight ]:
490.55

[ Exact Mass ]:
490.26400

[ PSA ]:
206.01000

[ LogP ]:
1.95660

Related Compounds

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