ON-01910

Names

[ Name ]:
ON-01910

[Synonym ]:
Glycine, N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, sodium salt (1:1)
Sodium {[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methyl)phenyl]amino}acetate
ON-01910
Estybon
Sodium {[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfo nyl}methyl)phenyl]amino}acetate

Biological Activity

[Description]:

Rigosertib (ON-01910) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)

[Target]

PLK1

[In Vitro]

Rigosertib (ON-01910) sodium 是一种非 ATP 竞争性 PLK1 抑制剂，IC50 为 9 nM，比 Plk2 选择性高 30 倍，对 Plk3 没有抑制活性。

[References]

[1]. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₄NNaO₈S

[ Molecular Weight ]:
473.47

[ Exact Mass ]:
473.112030

[ PSA ]:
131.60000

[ LogP ]:
2.62230

[ Storage condition ]:
-20℃

Related Compounds

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