4'-Methylacetophenone
Names
[ CAS No. ]:
122-00-9
[ Name ]:
4'-Methylacetophenone
[Synonym ]:
4’-Methylacetophenone
1-(p-Tolyl)ethanone
4‘-Methylacetophenone
Methyl p-tolyl ketone
1-Acetyl-4-methylbenzene
p-Acetyltoluene
EINECS 204-514-8
Methyl 4-methylphenyl ketone
p-Methyl acetophenone
1-p-Tolylethanone
p-Methylacetophenone
1-(4-Methylphenyl)ethanone
MFCD00000203
Ethanone, 1-(4-methylphenyl)-
4-Methylacetophenone
1VR D1
4-Acetyltoluene
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
211.0±9.0 °C at 760 mmHg
[ Melting Point ]:
45-49 °C(lit.)
[ Molecular Formula ]:
C9H10O
[ Molecular Weight ]:
134.175
[ Flash Point ]:
92.2±0.0 °C
[ Exact Mass ]:
134.073166
[ PSA ]:
17.07000
[ LogP ]:
2.13
[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.511
[ Water Solubility ]:
0.37 g/L (15 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AM9463000
- CHEMICAL NAME :
- Acetophenone, 4'-methyl-
- CAS REGISTRY NUMBER :
- 122-00-9
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C9-H10-O
- MOLECULAR WEIGHT :
- 134.19
- WISWESSER LINE NOTATION :
- 1VR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,933,1974
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,933,1974 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,933,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83203 No. of Facilities: 38 (estimated) No. of Industries: 2 No. of Occupations: 27 No. of Employees: 5690 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83203 No. of Facilities: 325 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3426 (estimated) No. of Female Employees: 2144 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315
[ Precautionary Statements ]:
P301 + P312 + P330
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S26-S27-S37/39-S24/25-S23
[ RIDADR ]:
UN 1325 4.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AM9463000
[ HS Code ]:
2914399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914399090
[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
Bioorg. Med. Chem. 16 , 1084-9, (2008)
Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Kinetic experiments were p...