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Mefenamic acid D4

Names

[ CAS No. ]:
1216745-79-7

[ Name ]:
Mefenamic acid D4

[Synonym ]:
2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid
Benzoic-2,3,4,5-d4 acid, 6-[(2,3-dimethylphenyl)amino]-

Biological Activity

[Description]:

Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

hCOX-1:40 nM (IC50)

hCOX-2:3 nM (IC50)


[References]

[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

[2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

Chemical & Physical Properties

[ Density]:
1.2±0.0 g/cm3

[ Boiling Point ]:
398.8±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H11D4NO2

[ Molecular Weight ]:
245.310

[ Flash Point ]:
195.0±0.0 °C

[ Exact Mass ]:
245.135391

[ LogP ]:
5.33

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.639

Related Compounds