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Protein Kinase C (19-31)

Names

[ CAS No. ]:
121545-65-1

[ Name ]:
Protein Kinase C (19-31)

[Synonym ]:
rfarkgalrqknv
protein kinase c fragment 19-31 amide
arg-phe-ala-arg-lys-gly-ala-leu-arg-gln-lys-asn-val-nh2
pkc inhibitor peptide
protein kinase c inhibitor peptide 19-31
h-arg-phe-ala-arg-lys-gly-ala-leu-arg-gln-lys-asn-val-oh
arg-phe-ala-arg-lys-gly-ala-leu-arg-gln-lys-asn-val

Biological Activity

[Description]:

Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Others
Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Mellor H, et al. The extended protein kinase C superfamily. Biochem J. 1998 Jun 1;332 ( Pt 2):281-92.

[2]. Nishizuka Y (1995). Protein kinase C and lipid signaling for sustained cellular responses" (abstract). FASEB J. 9 (7): 484–96.

Chemical & Physical Properties

[ Molecular Formula ]:
C67H118N26O16

[ Molecular Weight ]:
1543.82

[ Exact Mass ]:
1542.92000

[ PSA ]:
736.44000

[ LogP ]:
3.78570

Related Compounds