Gallinamide A

Names

[ CAS No. ]:
1208232-55-6

[ Name ]:
Gallinamide A

[Synonym ]:
symplostatin 4
Isoleucine, N,N-dimethyl-, 1-[[[1-[[[(2E)-4-(2,5-dihydro-3-methoxy-2-methyl-5-oxo-1H-pyrrol-1-yl)-1-methyl-4-oxo-2-buten-1-yl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-3-methylbutyl ester
1-[(1-{[(3E)-5-(3-Methoxy-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-5-oxo-3-penten-2-yl]amino}-4-methyl-1-oxo-2-pentanyl)amino]-4-methyl-1-oxo-2-pentanyl N,N-dimethylisoleucinate

Biological Activity

[Description]:

Gallinamide A is a potent inhibitor of cathepsin L with an IC50 value of 17.6 pM.

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Ashhurst AS, et al. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv [Preprint]. 2020 Dec 24:2020.12.23.424111.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
747.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₅₂N₄O₇

[ Molecular Weight ]:
592.77

[ Flash Point ]:
406.1±32.9 °C

[ Exact Mass ]:
592.383606

[ LogP ]:
5.48

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.522

Related Compounds

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