Big Endothelin-1 (1-39), porcine

Names

[ CAS No. ]:
120796-99-8

[ Name ]:
Big Endothelin-1 (1-39), porcine

[Synonym ]:
CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-ILE-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-SER-ARG-SER

Biological Activity

[Description]:

Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

[In Vitro]

Endothelin-1 (ET-1) is a potent, endothelial cell-derived, 21-amino acid peptide that has potent vasoconstricting properties and may participate in the regulation of blood pressure and regional blood flow[1].

[In Vivo]

Big Endothelin-1 (1-39), porcine, the cDNA deduced putative precursor of ET-1, has been reported to have similar pressor effects in vivo[1].

[References]

[1]. A Hoffman, et al. Opposite effects of endothelin-1 and Big-endothelin-(1-39) on renal function in rats. Eur J Pharmacol. 1990 Jul 17;182(3):603-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉₃H₂₈₉N₄₉O₅₈S₅

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Nature 332 , 411, (1988)

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin comp...

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

FEBS Lett. 231 , 440, (1988)

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary str...