(R)-α-Phenylcyclohexaneglycolic Acid 4-(Diethylamino)-2-butynyl Ester, Hydrochloride

Names

[ CAS No. ]:
1207344-05-5

[ Name ]:
(R)-α-Phenylcyclohexaneglycolic Acid 4-(Diethylamino)-2-butynyl Ester, Hydrochloride

[Synonym ]:
S547MDN7WX
24II7HX270
Ethanamine, N,N-diethyl-, hydrochloride (1:1)
EINECS 216-139-7
JWB87T68BN
N,N-Diethylethanamine hydrochloride (1:1)
0NX3818GCW
L9F3D9RENQ
Triethylammonium chloride
Triethylamine hydrochloride
MFCD00012500

Biological Activity

[Description]:

(R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittelforschung. 1998 Oct;48(10):1012-8.

[2]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912.

[3]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharm Res. 2001 Jul;18(7):1029-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₂ClNO₃

[ Molecular Weight ]:
393.95

[ Exact Mass ]:
137.097122